Climate change represents a major threat to the stability and health of Antarctic ecosystems. Understanding the fate of the organisms that call the land, water, ice and ocean of Antarctica home requires understanding how they will respond to these environmental changes. The aim of C-CAGE is to use the natural environmental gradients in temperature, ice cover, and other physical drivers that exist in different parts of Antarctica and the sub-Antarctic (with latitude, longitude, altitude and depth) to better predict the likely outcomes for life as the region’s habitats change. More reliable predictions of future ecological change will enable better management and conservation of Antarctica’s unique biodiversity and ecosystems.